A child’s own bone marrow stem cells can increase their treatment options

Apr 13, 2011
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Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of an early phase clinical trial at The University of Texas Health Science Center at Houston.

The study was reported to involve 10 children aged 5 to 14 years, who had severe Traumatic Brain Injury. Within 48 hours of the head injury each of the children had their own stem cells collected from their bone marrow. The stem cells were processed and returned to them.  The findings were very encouraging, and indicate that the procedure is safe.  It was considered too early to determine how effective the treatment will be, but at a six-month follow-up medical examination all of the children demonstrated significant improvement. Most encouraging, seven of the ten children with a new traumatic brain injury who received an injection of their own processed bone marrow stem cells had either mild or no disability at six months. This was considered remarkable because children who have survived severe TBI prior to this time were often left with serious complications and disability.

Adults: It is interesting to note that the University of Texas Health Department of Neurology is also testing the same procedure in adults with acute stroke.

FOR MORE INFORMATION: Science Daily http://www.sciencedaily.com/ (Mar. 11, 2011)

This report was based on results published in March 2011 issue of Neurosurgery, the journal of the Congress of Neurological Surgeons. University of Texas Health Science Center at Houston co-authors of the study include: Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery, Linda Ewing-Cobbs, Ph.D., professor, Department of Pediatrics; Khader M. Hasan, Ph.D., associate professor, Department of Diagnostic and Interventional Imaging; Mary-Clare Day, R.N., senior research nurse; Fernando Jimenez, M.S., senior research assistant, Department of Pediatric Neurosurgery; Peter A. Walker, M.D., and Shinil K. Shah, M.D., residents, Department of Surgery; and James Baumgartner, M.D., research collaborator, Department of Pediatric Surgery.

Author: Tanya